Generating Organ Structures

Jessica Rosenkrantz and colleagues adapt their biologically inspired software to meet the needs of bioengineers making blood vessel networks. twitter

Nervous System collaborated with bioengineers at Rice University to create complex blood vessel networks using generative design and 3D-printed sugar. In a paper published in Nature Biomedical Engineering, we showed that densely packed cells can be kept alive for 2 weeks using these complex blood vessel networks. post

Highly branched, tree-like vascular networks are very efficient at transporting oxygen and nutrients to cells. Our field has long been interested in incorporating such networks into engineered tissues. Actually making these networks in vitro presents a pair of questions: first, how to design the blueprints for networks with these complex branching features; and second, how to physically produce them. post

Sacrificial templates for patterning perfusable vascular networks in engineered tissues have been constrained in architectural complexity, owing to the limitations of extrusion-based 3D printing techniques. Here, we show that cell-laden hydrogels can be patterned with algorithmically generated dendritic vessel networks and other complex hierarchical networks by using sacrificial templates made from laser-sintered carbohydrate powders. nature